Computational Biologist I
Company: Freenome
Location: Brisbane
Posted on: July 10, 2025
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Job Description:
Freenome is a high-growth biotech company developing tests to
detect cancer using a standard blood draw. To do this, Freenome
uses a multiomics platform that combines tumor and non-tumor
signals with machine learning to find cancer in its earliest,
most-treatable stages. Cancer is relentless. This is why Freenome
is building the clinical, economic, and operational evidence to
drive cancer screening and save lives. Our first screening test is
for colorectal cancer (CRC) and advanced adenomas, and it’s just
the beginning. Founded in 2014, Freenome has ~400 employees and
continues to grow to match the scope of our ambitions to provide
access to better screening and earlier cancer detection. At
Freenome, we aim to impact patients by empowering everyone to
prevent, detect, and treat their disease. This, together with our
high-performing culture of respect and cross-collaboration, is what
motivates us to make every day count. Become a Freenomer Do you
have what it takes to be a Freenomer? A “Freenomer” is a
determined, mission-driven, results-oriented employee fueled by the
opportunity to change the landscape of cancer and make a positive
impact on patients’ lives. Freenomers bring their diverse
experience, expertise, and personal perspective to solve problems
and push to achieve what’s possible, one breakthrough at a time.
About this opportunity: At Freenome, we are seeking a Computational
Biologist I, Assay Development to help grow the Freenome’s
Computational Biology, Assay Development (CBAD) team. As part of
our team, you will apply your scientific expertise to the
development of early, noninvasive tests for cancer detection. With
a strong background in bioinformatics, statistics, and molecular
biology, you will develop, write, and execute analysis plans and
reports for the development and characterization of Freenome’s in
vitro diagnostic devices and regulatory filings. You will work
closely and cross-functionally with many teams, including
Regulatory and Quality, Molecular Research and Development,
Laboratory Operations, Biostatistics, Computational Science, and
Engineering to enable the successful development of multiple
molecular assays as part of Freenome’s diagnostic products. The
role reports to a Director of Computational Biology. This role can
be a hybrid role based in our Brisbane, California headquarters
(2-3 days per week in office), or remote. What you’ll do: Plan and
execute development experiments for Freenome’s multiomics cancer
screening tests. Partner cross-functionally with computational,
development, regulatory, and quality leaders to develop and execute
a regulated development strategy working toward FDA approval. Use
your quantitative skills to develop computational methods and
interpret complex experimental results in order to optimize and
validate innovative technology for sample collection, preparation,
and detection. Develop and execute appropriate experimental design
and analysis plans for Development, Verification, and Validation
studies, closely partnering with Biostatistics, Development, and
Pre-Analytics teams. Work closely with molecular and computational
research teams developing Freenome’s IVD products for blood-based
molecular assays involving cell-free DNA. Impact patient lives
through the development and launch of high quality cancer screening
technologies Must haves: Post-graduate degree (MS or PhD) in
statistics, computational biology, bioinformatics, cancer biology,
or related quantitative field. Experience in experimental design
and analysis of high-throughput, quantitative technologies in
genomics, epigenomics, or transcriptomics (e.g. target capture with
UMI, Hi-C, ATAC-seq, RNA-seq, bisulfite sequencing, microarrays).
Familiarity with and ability to select and leverage bioinformatics
tools for the above molecular assays. Experience in applied
statistics, such as in hypothesis testing, GLM, and appropriate use
of simulation. Expertise in data analysis and visualization using R
(tidyverse), or Python statistical packages (Numpy, Matplotlib,
Pandas), or equivalent, under version control. Excellent oral and
written communication skills to communicate to scientific and
broader audiences, with keen attention to detail. Ability to work
on a cross-functional team in our highly collaborative environment,
working with both computational and experimental scientists. Nice
to haves: Ability to work on a cross-functional team in our highly
collaborative environment, working with both computational and
experimental scientists. Benefits and additional information: The
US target range of our base salary/hourly rate for new hires is
$131,325 - $201,000. You will also be eligible to receive pre-IPO
equity, cash bonuses, and a full range of medical, financial, and
other benefits depending on the position offered. Please note that
individual total compensation for this position will be determined
at the Company’s sole discretion and may vary based on several
factors, including but not limited to, location, skill level, years
and depth of relevant experience, and education. Freenome is proud
to be an equal-opportunity employer, and we value diversity.
Freenome does not discriminate on the basis of race, color,
religion, marital status, age, national origin, ancestry, physical
or mental disability, medical condition, pregnancy, genetic
information, gender, sexual orientation, gender identity or
expression, veteran status, or any other status protected under
federal, state, or local law.
Keywords: Freenome, Gilroy , Computational Biologist I, Science, Research & Development , Brisbane, California
