Pharmacovigilance Medical Reviewer (Director)
Company: Nurix Therapeutics
Location: San Francisco
Posted on: July 10, 2025
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Job Description:
Nurix Therapeutics is a clinical stage biopharmaceutical company
focused on the discovery, development, and commercialization of
targeted protein degradation medicines, the next frontier in
innovative drug design aimed at improving treatment options for
patients with cancer and inflammatory diseases. Powered by a fully
AI-integrated discovery engine capable of tackling any protein
class, and coupled with unparalleled ligase expertise, Nurix’s
dedicated team has built a formidable advantage in translating the
science of targeted protein degradation into clinical advancements.
Nurix aims to establish degrader-based treatments at the forefront
of patient care, writing medicine’s next chapter with a new script
to outmatch disease. Position: We are seeking a Pharmacovigilance
Medical Reviewer to support safety activities for investigational
products in clinical development. This role is focused on the
medical review and evaluation of individual case safety reports
(ICSRs), with an emphasis on early-phase and late-phase clinical
trials. The ideal candidate will also be poised to support
post-marketing pharmacovigilance activities as our pipeline
progresses to commercialization. The Medical Reviewer will be
responsible for providing medical expertise in the evaluation and
reporting of adverse events, ensuring compliance with global
pharmacovigilance regulations, and contributing to the safety
profile assessment of Nurix’s pharmaceutical products throughout
their lifecycles. Responsibilities: Perform medical review of
clinical trial ICSRs, ensuring timely and accurate assessment of
seriousness, expectedness, and causality Write Analysis of Similar
Events (AOSE) Collaborate with Safety Scientists and Clinical teams
on ongoing safety surveillance, including signal detection and
trend analyses Participate in Safety Review Committee (SRC)
meetings, Data Monitoring Committees (DMCs), and safety governance
meetings, as needed and provide medical input into safety-related
decisions Analyze safety data to identify potential signals and
trends requiring further investigation Contribute to the
preparation of Development Safety Update Reports (DSURs) and Risk
Management Plans (RMPs), and Periodic Safety Update Reports
(PSURs), Support expedited reporting of serious adverse events to
regulatory authorities within required timelines Contribute to the
benefit-risk assessments and assist in the development,
implementation, and evaluation of risk minimization measures Review
product labeling from a safety perspective and recommend
appropriate updates Collaborate with cross functional teams to
ensure alignment on safety-related topics Provide medical expertise
to support responses to safety queries from regulatory authorities
Contribute to the development of company-specific MedDRA queries
for signal detection Serve as a safety representative in
cross-functional teams and project meetings Provide training and
oversight of external vendor to promote high quality medical
review, writing concise medical queries and causality assessment
Perform additional PV related responsibilities as delegated by
supervisor Education and Experience MD, PharmD, or RN degree
required Experience supporting oncology trials Minimum 5 years of
experience in pharmacovigilance performing medical review
Proficient with safety databases (e.g., Argus, ARISg) and MedDRA
coding Clinical acumen with the ability to interpret safety data
and assess adverse events in context. Excellent communication
skills and ability to collaborate cross-functionally Strong
analytical skills with ability to interpret complex medical and
scientific data Excellent written and verbal communication skills
Proficiency in medical writing, particularly safety narratives and
case evaluations Personal Attributes Meticulous attention to detail
and strong quality focus Ability to work effectively in fast paced
setting and meet strict deadlines Excellent interpersonal skills
with ability to collaborate across functions Self-motivated with
capacity to work independently and as part of a team Nurix
Therapeutics, Inc. is committed to protecting and respecting your
privacy and personal information, including information collected
by Nurix when you apply for a job with Nurix or in the course of
your employment with Nurix. By applying for a position at Nurix,
you agree to our collection and use of personal information as
described in our Privacy Policy (
https://www.nurixtx.com/privacy-policy/ ).
Keywords: Nurix Therapeutics, Gilroy , Pharmacovigilance Medical Reviewer (Director), Science, Research & Development , San Francisco, California
