Senior Manager, Data Management
Company: 4D Molecular Therapeutics
Location: Emeryville
Posted on: February 7, 2026
|
|
|
Job Description:
Attention recruitment agencies: All agency inquiries are vetted
through 4DMT’s internal Talent Acquisition team. No unsolicited
resumes will be accepted. The 4DMT Talent Acquisition team must
expressly engage agencies on any requisition. Agencies contacting
hiring managers directly will not be tolerated, and doing so may
impact your ability to work with 4DMT in the future. 4DMT is a
leading late-stage biotechnology company advancing durable and
disease-targeted therapeutics with potential to transform treatment
paradigms and provide unprecedented benefits to patients. The
Company’s lead product candidate 4D-150 is designed to be a
backbone therapy forming the foundation of treatment of blinding
retinal vascular diseases by providing multi-year sustained
delivery of anti-VEGF (aflibercept and anti-VEGF-C) with a single,
safe, intravitreal injection, which substantially reduces the
treatment burden associated with current bolus injections. The
Company’s lead indication for 4D-150 is wet age-related macular
degeneration, which is currently in Phase 3 development, and second
indication is diabetic macular edema. The Company’s second product
candidate is 4D-710, which is the first known genetic medicine to
demonstrate successful delivery and expression of the CFTR
transgene in the lungs of people with cystic fibrosis after aerosol
delivery GENERAL SUMMARY: The Senior Manager, Data Management leads
execution of end?to?end clinical data management activities for
assigned studies and provides operational oversight to internal
staff and external vendors. This role serves as a key member of
cross?functional study teams, contributing to planning, execution,
and delivery of high?quality clinical trial data across all phases.
The Senior Manager possesses robust working knowledge of clinical
data management processes and independently executes most tasks
while also providing guidance to other Data Managers and vendor
partners. Data management is one of the essential functions of the
Clinical Development organization at 4DMT. Together with the other
two functions within the Data Science group, Biostatistics, and
Statistical Programming, we provide critical support for the
company’s clinical development programs in gene therapies for
retina diseases and other therapeutic areas. MAJOR DUTIES &
RESPONSIBILITIES: Manage end?to?end Data Management activities for
one or more clinical studies with moderate guidance from line
manager. Oversee daily study?level data management operations,
ensuring compliance to timelines, quality standards, and SOPs.
Support vendor oversight activities, including reviewing timelines,
deliverables, and quality metrics. Contribute to risk
identification and mitigation strategies for data?related issues.
Review study protocols to ensure appropriate data capture elements
and eCRF design. Support the development of eCRF specifications and
contribute to review of data requirements. Assist in coordinating
EDC system design, testing, and UAT, ensuring adherence to company
standards. Contribute and/or author Data Management Plans, Data
Transfer Plans, and other study?related documents Support review of
clinical monitoring plans, SAPs, and vendor specifications. Monitor
data quality and cleaning activities, including management of data
listings and reconciliation efforts. Partner with CROs and external
vendors to ensure timely and high?quality data deliverables.
Participate in study team meetings, providing updates on Data
Management metrics and timelines. Escalate issues appropriately to
line manager, data management leadership or other functional leads.
Oversee reconciliation activities (e.g., header data, SAE
reconciliation) performed by CROs. Support database upgrades and
migrations, including contribution to UAT. Participate in database
snapshot, lock, and freeze activities. Provide day?to?day guidance
and mentorship to Data Managers. Deliver training to internal and
external team members on EDC systems or eCRF completion guidelines
as needed. Maintain Data Management documentation and eTMF files.
Other duties assigned: nothing in this job description restricts
management’s right to assign or reassign duties and
responsibilities to this job at any time. QUALIFICATIONS:
Education: B.A./B.S. degree or higher (life-science-related fields
preferred) or equivalent experience. Experience: 7 years of data
management experience in the biotech/pharmaceutical industry or
clinical data management service providers of which at least three
(3) years in a lead study data manager role. Experience with Phase
1-3 clinical trials required: retina diseases and/or gene therapies
experience a plus. Demonstrated experience in vendor oversight and
cross?functional team leadership. Experience in vendor management
and performance assessments In-depth knowledge and experience with
CDISC data standards and models. Other Qualifications/Skills:
Proficient in using clinical data management systems (e.g.,
Medidata Rave) and the data flow, including those from external
sources (IRT, safety, central/specialty labs, reading centers,
PROs, etc.) Proficiency in data management process and knowledge of
Good Clinical Data Management Practices (GCDMP) in global clinical
trials Knowledge of ICH GCP and other applicable regulatory rules
and guidelines. Knowledge of the clinical development process
Proficient with MS Office (Worl, Excel, PowerPoint, etc.) Strong
communication and interpersonal skills (written and verbal)
Collaborative mindset with ability to work effectively. High
attention to detail with excellent organizational and
time?management capabilities. Ability to manage multiple projects
in a fast-paced environment Proven conceptual, analytical and
strategic thinking Excellent attention to details Travel: 0-10%,
based on study needs. Physical Requirements and Working Conditions:
Physical Activity - Repetitive motions: Making substantial
movements (motions) of the wrists, hands, and/or fingers.
Fingering: Picking, pinching, typing or otherwise working,
primarily with fingers rather than with whole hand or arm as in
handling. Talking: Expressing or exchanging ideas by means of the
spoken word. Physical Requirements - Sedentary work: Exerting up to
10 pounds of force occasionally and/or a negligible amount of force
frequently or constantly to lift, carry, push, pull or otherwise
move objects, including the human body. Sedentary work involves
sitting most of the time. Jobs are sedentary if walking and
standing are required only occasionally, and all other sedentary
criteria are met. Working Conditions - The worker is not
substantially exposed to adverse environmental conditions (as in
typical office or administrative work). Base salary compensation
range: $178,000 - 208,000 Please note, the base salary compensation
range and actual salary offered to the final candidate depends on
various factors: candidate’s geographical location, relevant work
experience, skills, and years of experience. 4DMT provides equal
employment opportunities to all employees and applicants for
employment without regard to race, color, religion, gender, sexual
orientation, national origin, age, disability, genetic information,
marital status, status as a covered veteran, and any other category
protected under applicable federal, state, provincial and local
laws. Equal Opportunity Employer/Protected Veterans/Individuals
with Disabilities
Keywords: 4D Molecular Therapeutics, Gilroy , Senior Manager, Data Management, Science, Research & Development , Emeryville, California
